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- 11px);left:10px;}.btn-default.icon-acount:before{content:url(/themes/custom/opdivo_theme/images/common/icon/acount-ffffff.svg);width:1.25rem;display:inline-block;vertical-align:middle;margin-right:.5rem;}.btn-default .ico-pdf:before{content:"";background-image:url(/themes/custom/opdivo_theme/images/common/icon/pdf.svg);height:1.375rem;width:1.2rem;background-size:1.2rem 1.2rem;background-repeat:no-repeat;display:inline-block;vertical-align:middle;}.btn-default .ico-ppt:before{content:"";background-image:url(/themes/custom/opdivo_theme/images/common/icon/powerpoint.svg);height:1.375rem;width:1.2rem;background-size:1.2rem 1.2rem;background-repeat:no-repeat;display:inline-block;vertical-align:middle;}.btn-default.suppression{color:#0d92be;background:#cfe5ee;border-bottom:2px solid #a6b7be;}.btn-default.emphasis{color:#fff;background:#de5900;border-bottom:2px solid #b24700;}.btn-default.auxiliary{color:#0d92be;background:#eee;border-bottom:2px solid #ccc;}.btn-default.yervoy{font-weight:normal;color:#333;background:#fed7bd;border-bottom:2px solid #fda66e;}.btn-default.more{font-size:.875rem;padding:.25rem 3.5rem .25rem 2.6rem;position:relative;width:100%;max-width:190px;}.btn-default.more:after{position:absolute;right:.7rem;top:calc(50% - 5px);content:'';width:10px;height:10px;display:block;-webkit-box-sizing:border-box;box-sizing:border-box;background-image:url(/themes/custom/opdivo_theme/images/common/icon/arrow-down-mid-ffffff.svg);background-repeat:no-repeat;background-position:center center;}.btn-default.small{width:100%;max-width:200px;font-size:.875rem;}.btn-default.is-disabled{background-color:#f3f3f3;border-bottom-color:#c2c2c2;color:#aaa;cursor:not-allowed;}.btn-default.is-disabled:hover{opacity:1;}.btn-default.is-disabled.icon-download:before{content:url(/themes/custom/opdivo_theme/images/common/icon/download.svg);}.btn-default .ico-member:before,.btn-default 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.link-angle:before{background-image:url(/themes/custom/opdivo_theme/images/common/icon/arrow-right-mid-ffffff.svg);}.link-angle.white,.link-angle-down.white{color:#fff;}.link-angle.white:before,.link-angle-down.white:before{border-color:#fff;}.link-angle:hover,.link-angle-up:hover,.link-angle-down:hover{text-decoration:underline;}.link-angle-down:visited{color:#039;}.ttl-h2{color:#003b5c;font-size:1.375rem;font-weight:bold;border-bottom:2px solid #003b5c;margin-bottom:1.375rem;}.basic-info .ttl-h2 img{max-width:100%;}.ttl-h3{color:#003b5c;padding-left:.5rem;font-size:1.125rem;font-weight:bold;border-left:3px solid #003b5c;margin-bottom:1.125rem;}.ttl-h4{color:#003b5c;font-weight:bold;margin-bottom:1rem;}.ttl-blue{background:#0d92be;color:#fff;font-weight:bold;font-size:1.125rem;padding:0.56rem 2.25rem calc(.56rem - 3px) 1.125rem;position:relative;border-bottom:3px solid #0d92be;}.ttl-rightblue{background:#f3f3f3;color:#008cba;font-weight:bold;font-size:1.125rem;padding:0.56rem 1.125rem calc(.56rem - 3px) 1.125rem;margin-bottom:.875rem;position:relative;}.ttl-rightblue.js-toggle-trigger{padding:0.56rem 2.25rem calc(.56rem - 3px) 1.125rem;margin-bottom:0;}.ttl-rightblue.js-toggle-trigger:after,.ttl-blue:after{position:absolute;right:.8rem;top:calc(50% - 5px);content:'';width:15px;height:15px;display:block;-webkit-box-sizing:border-box;box-sizing:border-box;background-image:url(/themes/custom/opdivo_theme/images/common/icon/arrow-down-mid-ffffff.svg);background-repeat:no-repeat;background-position:center center;}.ttl-rightblue.js-toggle-trigger:after{background-image:url(/themes/custom/opdivo_theme/images/common/icon/arrow-down-mid-333.svg);}.ttl-rightblue.js-toggle-trigger.is-open:after,.ttl-blue.is-open:after{top:calc(50% - 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.mod-pagination-inner:after{content:'';visibility:hidden;display:block;height:0;clear:both;}.mod-pagination > .mod-pagination-inner > ul{margin:auto;margin-bottom:1rem;}.mod-pagination > .mod-pagination-inner > ul:first-child{float:left;}.mod-pagination > .mod-pagination-inner > ul:nth-child(2){float:right;}.mod-pagination > .mod-pagination-inner > ul:last-child{padding:0 1rem;display:inline-block;text-align:center;clear:both;margin-bottom:0;}.mod-pagination > .mod-pagination-inner > ul:after{content:'';visibility:hidden;display:block;height:0;clear:both;}.mod-pagination > .mod-pagination-inner > ul > li{float:left;display:table;width:36px;height:36px;margin-bottom:0;}.mod-pagination > .mod-pagination-inner > ul > li > a,.btn-arrow{border:1px solid #ddd;border-radius:3px;-webkit-box-sizing:border-box;box-sizing:border-box;vertical-align:middle;text-align:center;display:table-cell;text-decoration:none;color:#333;}.btn-arrow,a.btn-arrow{display:block;width:100%;max-width:190px;margin:auto auto 1rem auto;color:#333;}.mod-pagination > .mod-pagination-inner > ul > li > a:hover,.mod-pagination > .mod-pagination-inner > ul > li > a.is-active,.btn-arrow:hover,.btn-arrow.is-active{background:#003b5c;font-weight:bold;color:#fff;border-color:#003b5c;}.mod-pagination > .mod-pagination-inner > ul > li > span{vertical-align:middle;text-align:center;display:table-cell;}.mod-pagination > .mod-pagination-inner > ul > li + li{margin-left:2px;}.mod-pagination > .mod-pagination-inner > ul:not(:last-child) > 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*{min-height:0%;}.grid-col-sp7{display:-webkit-box;display:-ms-flexbox;display:flex;-webkit-box-orient:vertical;-webkit-box-direction:normal;-ms-flex-direction:column;flex-direction:column;margin-left:5px;margin-right:5px;-webkit-box-sizing:border-box;box-sizing:border-box;width:calc(58.333% - 10px);float:left;}.grid-col-sp7 *{min-height:0%;}.grid-col-sp8{display:-webkit-box;display:-ms-flexbox;display:flex;-webkit-box-orient:vertical;-webkit-box-direction:normal;-ms-flex-direction:column;flex-direction:column;margin-left:5px;margin-right:5px;-webkit-box-sizing:border-box;box-sizing:border-box;width:calc(66.6666% - 10px);float:left;}.grid-col-sp8 *{min-height:0%;}.grid-col-sp12{display:-webkit-box;display:-ms-flexbox;display:flex;-webkit-box-orient:vertical;-webkit-box-direction:normal;-ms-flex-direction:column;flex-direction:column;margin-left:5px;margin-right:5px;-webkit-box-sizing:border-box;box-sizing:border-box;width:calc(100% - 10px);}}@media screen and (min-width:768px) and (max-width:999px){.grid-col-tb3{margin-top:0;display:block;margin-left:10px;margin-right:10px;-webkit-box-sizing:border-box;box-sizing:border-box;width:calc(25% - 20px);float:left;}.grid-col-tb3 *{min-height:0%;}.grid-col-tb6{display:-webkit-box;display:-ms-flexbox;display:flex;-webkit-box-orient:vertical;-webkit-box-direction:normal;-ms-flex-direction:column;flex-direction:column;width:calc(50% - 20px) !important;margin-left:10px;margin-right:10px;-webkit-box-sizing:border-box;box-sizing:border-box;float:left;}.grid-col-tb6 *{min-height:0%;}.grid-col-tb12{display:-webkit-box;display:-ms-flexbox;display:flex;-webkit-box-orient:vertical;-webkit-box-direction:normal;-ms-flex-direction:column;flex-direction:column;margin-left:10px;margin-right:10px;-webkit-box-sizing:border-box;box-sizing:border-box;width:calc(100% - 20px) !important;}}.nonsem-center{-webkit-align-items:center;align-items:center;}.form-input{margin-bottom:.8rem;}.form-input[type=search],.form-input[type=text],.form-input[type=email],.form-input[type=number],.form-input[type=tel]{border:1px solid #ccc;outline:none;padding:.5rem;font-size:1.125rem;-webkit-box-shadow:inset 0 2px 3px 0 rgba(0,0,0,0.1);box-shadow:inset 0 2px 3px 0 rgba(0,0,0,0.1);-webkit-box-sizing:border-box;box-sizing:border-box;border-radius:6px;padding:.5rem;}.form-input[type="radio"],.form-input[type="checkbox"]{display:none;}.form-input[type="radio"]:checked + span:after,.form-input[type="checkbox"]:checked + span:after{display:block;}.form-input[type="radio"]:checked + span{background:#0099ff;border:none;}.form.small[type=search],.form.small[type=text]{font-size:.75rem;}.form-rows > label{font-size:.875rem;display:inline-block;}.form-rows > label:not(:last-child){margin-right:1rem;}.form-rows > label > span{margin-right:4px;top:2px;position:relative;display:inline-block;width:14px;height:14px;}.form-rows > label > span:after{content:'';position:absolute;display:none;}.form-rows.radio > label{text-indent:-18px;padding-left:18px;cursor:pointer;}.form-rows.radio > label > span{border-radius:50%;border:1px solid #b1b1b1;-webkit-box-sizing:border-box;box-sizing:border-box;-webkit-box-shadow:inset 0 1px 2px 0 #ccc;box-shadow:inset 0 1px 2px 0 #ccc;}.form-rows.radio > label > span:after{top:5px;left:5px;width:4px;height:4px;border-radius:50%;background:#fff;-webkit-box-shadow:0 1px 3px 0 rgba(0,0,0,0.2);box-shadow:0 1px 3px 0 rgba(0,0,0,0.2);}.form-rows.checkbox > label{text-indent:-20px;padding-left:20px;cursor:pointer;}.form-rows.checkbox > label > span{border:1px solid #ccc;-webkit-box-shadow:inset 0 1px 3px 0 rgba(0,0,0,0.3);box-shadow:inset 0 1px 3px 0 rgba(0,0,0,0.3);}.form-rows.checkbox > label > span:after{top:0;left:5px;width:4px;height:10px;border-right:1px solid #333;border-bottom:1px solid #333;-webkit-transform:rotate(45deg);-ms-transform:rotate(45deg);transform:rotate(45deg);}.form-button{border:none;}.form-label{font-size:.875rem;font-weight:bold;}.form-rows + hr{margin:10px 0;}.contents-main{background:#fff;}.contents-main-body{padding:1.875rem;padding-top:0;-webkit-box-sizing:border-box;box-sizing:border-box;}.sec-secondary{margin-bottom:1.875rem;}.sec-secondary:after{content:'';visibility:hidden;height:0;display:block;clear:both;}.sec-secondary > *:last-child{margin-bottom:0;}.ttl-h1{-webkit-box-sizing:border-box;box-sizing:border-box;position:relative;display:table;width:100%;overflow:hidden;margin-bottom:1rem;z-index:0;}.ttl-h1:not(.no-image){background:#f3f3f3;}.ttl-h1 .img-wrap{display:table-cell;position:relative;overflow:hidden;}.ttl-h1 .img-wrap:after{content:'';display:table-cell;}.ttl-h1 .img-wrap > img{position:absolute;top:0;right:0;display:block;width:100%;}.ttl-h1 .txt-wrap{position:relative;z-index:1;display:table-cell;-webkit-box-sizing:border-box;box-sizing:border-box;vertical-align:middle;overflow:visible;}.ttl-h1 .series{font-weight:bold;font-size:1.125rem;display:block;color:#003b5c;}.ttl-h1 .shoulder{font-weight:bold;font-size:1rem;display:block;color:#003b5c;}.ttl-h1 .title{color:#008cba;font-weight:bold;font-size:2.25rem;width:100%;-webkit-box-sizing:border-box;box-sizing:border-box;display:block;}.title .ico-label{display:inline-block;vertical-align:middle;margin-left:10px;}.ttl-h1.series-top .series{font-size:1rem;}.ttl-h1.series-top .shoulder{font-size:.875rem;}.ttl-h1.popup .series{font-size:0.875rem;}.ttl-h1.series-top .title{font-size:1.5rem;}.ttl-h1.popup .title{font-size:1.375rem;}.txt-update{font-size:.875rem;margin-bottom:.875rem;}.txt-update > dt,.txt-update > dd{display:inline-block;}@media screen and (max-width:767px){.ttl-h1.no-image{padding:10px;padding-bottom:0;}.ttl-h1 .img-wrap{width:216px;}.ttl-h1.series-top .img-wrap{width:180px;}.ttl-h1 .img-wrap:after{height:90px;}.ttl-h1 .img-wrap > img{opacity:.5;}.ttl-h1.series-top .img-wrap:after{height:72px;}.ttl-h1.series-top .txt-wrap{width:calc(100% - 180px);}.ttl-h1.series-top .txt-wrap .title,.ttl-h1.series-top .txt-wrap .series,.ttl-h1.series-top .txt-wrap .shoulder{width:calc(100% + 180px);}.ttl-h1 .txt-wrap{width:calc(100% - 216px);}.ttl-h1 .txt-wrap .title,.ttl-h1 .txt-wrap .series,.ttl-h1 .txt-wrap .shoulder{width:calc(100% + 216px);}}@media screen and (min-width:768px) and (max-width:999px){.ttl-h1.no-image{padding:10px;padding-bottom:0;}.ttl-h1 .img-wrap{width:288px;}.ttl-h1.series-top .img-wrap{width:240px;}.ttl-h1 .img-wrap:after{height:120px;}.ttl-h1.series-top .img-wrap:after{height:96px;}.ttl-h1 .txt-wrap{width:calc(100% - 288px);padding:10px;}.ttl-h1 .txt-wrap .title,.ttl-h1 .txt-wrap .series,.ttl-h1 .txt-wrap .shoulder{width:calc(100% + 80px);}}@media screen and (max-width:999px){.ttl-h1 .title{font-size:22px;}.ttl-h1 .txt-wrap{padding:10px;}.contents-main-body{padding:10px;padding-top:0;}.ttl-h1 .txt-wrap .title{text-shadow:0px 0px 6px #f3f3f3;}}@media screen and (min-width:1000px){.ttl-h1.no-image{padding:1.875rem;padding-bottom:0;}.ttl-h1.no-image  .title:first-child{}.ttl-h1 .img-wrap{width:360px;}.ttl-h1 .title:first-child{font-size:38px;}.ttl-h1.series-top .img-wrap{width:300px;}.ttl-h1.series-top .title:first-child{font-size:1.75rem;}.ttl-h1.no-image .title{font-size:1.75rem;}.ttl-h1 .img-wrap > img{width:66%;}.ttl-h1 .img-wrap:after{height:100px;}.ttl-h1.series-top .img-wrap:after{height:80px;}.ttl-h1 .txt-wrap{width:calc(100% - 360px);padding:0 1.875rem;}.ttl-h1 .txt-wrap .title,.ttl-h1 .txt-wrap .series,.ttl-h1 .txt-wrap .shoulder{width:calc(100% + 120px);line-height:1.5;}.ttl-h1 .txt-wrap .title-clinical-path{width:calc(100% + 140px);line-height:1.5;}.contents-right{width:260px !important;float:right;clear:right;}.contents-left{width:calc(100% - 300px);float:left;}}header .header{background:#fff;-webkit-box-sizing:border-box;box-sizing:border-box;}body > .header-top{background:#014ea0;position:relative;z-index:99;}body .header-top-in{height:30px;display:table;}body .header-top-in a{display:table-cell;vertical-align:middle;}body > .header-top a{font-size:.75rem;color:#fff;text-decoration:none;}body > .header-top a:before{content:'';display:inline-block;height:.5rem;width:.5rem;border-top:1px solid #fff;border-right:1px solid #fff;margin-right:.3rem;-webkit-box-sizing:border-box;box-sizing:border-box;-webkit-transform:rotate(-135deg) translate(-0.1rem,0.1rem);-ms-transform:rotate(-135deg) translate(-0.1rem,0.1rem);transform:rotate(-135deg) translate(-0.1rem,0.1rem);vertical-align:middle;}body > .header-top a > img{width:100%;max-width:90px;display:inline-block;vertical-align:middle;}body > .header-top a > span{display:inline-block;vertical-align:middle;margin-left:.5rem;line-height:1;}header .header-logo img{display:block;width:100%;}header .header-description{color:#666;}.for-patients .header-description{display:none;}header.popup-header .header{padding-right:74px;position:relative;}header.popup-header .header-description{width:calc(100% - 228px);padding:0 10px;}.popup-header .popup-close{padding-top:8px;display:block;position:absolute;width:72px;height:100%;border-left:2px solid #cde4e9;background-image:url(/themes/custom/opdivo_theme/images/common/icon/popup-close.svg);right:0;top:-8px;background-repeat:no-repeat;background-position:50% calc(50% + 4px);background-size:60%;}@media screen and (min-width:768px) and (max-width:999px){header.popup-header .header{padding-right:0;}.popup-header .popup-close{height:75px;top:0;}header.popup-header .header-description{width:calc(100% - 240px);padding-right:84px;}}@media screen and (max-width:767px){header.popup-header .header{padding-right:0;}header.popup-header .header-logo{}header.popup-header .header-description{width:calc(100% - 94px);}}.popup-header .popup-close a{display:block;position:absolute;width:72px;height:100%;right:0;top:0;text-indent:100%;white-space:nowrap;overflow:hidden;font-size:0;}.nav-global-greeting-wrap{font-weight:bold;}.nav-global-greeting{margin-right:1rem;font-weight:normal;}.nav-global [class|="ico"]{line-height:0.8rem;}.nav-global .ico-member:before{content:url(/themes/custom/opdivo_theme/images/common/icon/locked-white-yellow.svg);vertical-align:baseline;}@media screen and (min-width:1000px){.nav-global-greeting{text-align:right;font-size:85%;display:block;line-height:1;margin-right:0;}.nav-global-user + span{font-size:85%;}}.nav-global-btn{height:30px;-webkit-box-sizing:border-box;box-sizing:border-box;}.nav-global-btn:hover{opacity:.75;}.nav-global-search{position:relative;background:#ccd8de;-webkit-box-shadow:inset 0 1px 2px 0 #a3afb6;box-shadow:inset 0 1px 2px 0 #a3afb6;}.nav-global-search input[type=search],.nav-global-search 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li{display:table-cell;vertical-align:middle;width:34px;text-align:center;-webkit-box-sizing:border-box;box-sizing:border-box;line-height:1.5;color:#fff;text-decoration:none;font-weight:bold;cursor:pointer;}.nav-global-fontsize > ul > li[name="font-large"]{font-size:1.25rem;}.nav-global-fontsize > ul > li.is-active{background:#cfe5ee;-webkit-box-shadow:inset 0 -2px 0 0 #b8cbd2;box-shadow:inset 0 -2px 0 0 #b8cbd2;border-radius:3px;color:#003b5c;}.mod-breadcrumb{padding-bottom:.625rem;}.mod-breadcrumb li{display:inline-block;position:relative;margin-right:20px;}.mod-breadcrumb li span{font-size:.75rem;}.mod-breadcrumb li a{color:#003b5c;}.mod-breadcrumb li:not(:last-child):after{content:'';width:14px;height:16px;background-image:url(/themes/custom/opdivo_theme/images/common/icon/arrow-right-thin-014ea0.svg);background-repeat:no-repeat;background-position:center center;position:absolute;right:-21px;top:5px;}.mod-breadcrumb li:last-child a,.mod-breadcrumb li:last-child span{text-decoration:none;font-weight:bold;}@media screen and (max-width:767px){header .header{display:block;}header .header-logo{display:block;width:65%;max-width:208px;}header .header-description{display:block;padding:0 10px 12px 10px;}.nav-global-greeting-wrap{font-size:1.125rem;}.nav-global-btn{font-size:1rem;}.nav-global-wrap nav > ul li a:not(.banner){font-size:1rem;padding-top:0.725rem !important;padding-bottom:0.725rem !important;}.nav-global-is-content{padding:1rem .5rem;}.nav-global-is-content > .banner{font-size:1.125rem;}.nav-global-switch{border-radius:50%;background:#003b5c;-webkit-box-shadow:0 2px 6px 1px rgba(0,0,0,0.5);box-shadow:0 2px 6px 1px rgba(0,0,0,0.5);}.nav-global-switch > div > span,.nav-global-switch > div:before,.nav-global-switch > div:after{background:#fff;}.nav-global-switch > span:before{color:#fff;}}@media screen and (min-width:768px) and (max-width:999px){body.is-nv-open{top:0 !important;overflow:hidden;}header{position:relative;z-index:100;}header .header{display:table;height:75px;}header .header-logo{display:table-cell;width:210px;vertical-align:middle;}header .header-description{display:table-cell;-webkit-box-sizing:border-box;box-sizing:border-box;padding:12px 70px 12px 0;width:calc(100% - 180px);vertical-align:middle;}.nav-global{right:-280px !important;}body.is-nv-open .nav-global{position:absolute!important;top:75px !important;}.nav-global.is-active{right:0 !important;position:absolute!important;top:75px !important;}.nav-global-switch{position:absolute !important;top:5px;right:0 !important;}.nav-global-switch > div > span,.nav-global-switch > div:before,.nav-global-switch > div:after{background:#003b5c;}.nav-global-switch > span:before{color:#003b5c;}}@media screen and (max-width:999px){body{width:100%;}body.is-nv-open{position:fixed;}body .header-top-in{height:40px;padding-left:10px;}header .header-logo{padding:15px 20px 15px 10px;}header .header-description{font-size:.625rem;}.nav-global{overflow:auto !important;width:100%;top:0;max-width:280px !important;min-width:0 !important;position:fixed;z-index:99;right:-100%;-webkit-transition-duration:300ms;transition-duration:300ms;-webkit-transition-property:right;transition-property:right;-webkit-transform:translateZ(0);-ms-transform:translateZ(0);transform:translateZ(0);}.nav-global.is-active{right:0%;height:100%;}.nav-global-status-menu{background:#003b5c;color:#fff;}.nav-global-greeting-wrap{padding:.2rem .5rem;-webkit-box-sizing:border-box;box-sizing:border-box;border-top:2px solid #00517e;border-bottom:2px solid #00283e;}.nav-global-btns{display:table;width:100%;border-top:2px solid #00517e;border-bottom:2px solid #00283e;}.nav-global-btn,a.nav-global-btn{padding:.5rem 0;-webkit-box-sizing:border-box;box-sizing:border-box;display:table-cell;width:calc((100% - 55px) / 2);box-sizing:border-box;border-right:2px solid #00283e;vertical-align:middle;text-align:center;color:#fff;text-decoration:none;}.nav-global-btn + .nav-global-btn{border-left:2px solid #00517e;}.nav-global-btn.js-toggle-trigger{width:55px;}.nav-global-btn.js-toggle-trigger:after{background:url(/themes/custom/opdivo_theme/images/common/icon/search-ffffff.svg) no-repeat;content:'';height:16px;width:16px;display:block;margin:auto;}.nav-global-search{background:none;}.nav-global-search > div{border-top:2px solid #00517e;border-bottom:2px solid #00283e;-webkit-box-sizing:border-box;box-sizing:border-box;padding:10px .5rem;height:50px;}.nav-global-search > div > div{-webkit-box-sizing:border-box;box-sizing:border-box;height:30px;width:100%;border-radius:6px;background:#ccd8de;-webkit-box-shadow:inset 0 1px 2px 0 #a3afb6;box-shadow:inset 0 1px 2px 0 #a3afb6;}.nav-global-search input[type="search"]{padding:4px 40px 4px 4px;}.nav-global-search button{right:20px;top:calc(50% - 6px);}.nav-global-fontsize{display:none;}.nav-global-switch{display:block;position:fixed;z-index:101;bottom:48px;right:calc(50% - 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scaleX(1.2);transform:rotate(45deg) translate(0,10px) scaleX(1.2);}.nav-global-switch.is-close > div:before{opacity:0;}.nav-global-switch.is-close > div:after{-webkit-transform:rotate(-45deg) translate(0,-10px) scaleX(1.2);-ms-transform:rotate(-45deg) translate(0,-10px) scaleX(1.2);transform:rotate(-45deg) translate(0,-10px) scaleX(1.2);}.nav-global-switch.is-close > span:before{content:'CLOSE';}.nav-global-switch.is-close + .nav-global-mat{height:100%;width:100%;background:rgba(0,0,0,0.5);position:fixed;top:0;left:0;z-index:98;}.nav-global-wrap nav > ul li a{-webkit-box-sizing:border-box;box-sizing:border-box;}.nav-global-wrap nav > ul li a:not(.banner){color:#333;display:block;padding:.6rem;padding-right:30px;text-decoration:none;border-top:1px solid #999;-webkit-box-sizing:border-box;box-sizing:border-box;position:relative;}.nav-global-wrap nav > ul li a:not(.banner):not(.banner):not(.js-toggle-trigger):after{width:8px;height:8px;position:absolute;top:calc(50% - 4px);right:1rem;content:'';display:block;border-top:1px solid #333;border-right:1px solid #333;-webkit-box-sizing:border-box;box-sizing:border-box;-webkit-transform:rotate(45deg);-ms-transform:rotate(45deg);transform:rotate(45deg);}.nav-global-wrap nav > ul li a:not(.banner).js-toggle-trigger:after{width:2px;height:10px;position:absolute;top:calc(50% - 5px);right:1rem;content:'';display:block;background:#333;-webkit-box-sizing:border-box;box-sizing:border-box;-webkit-transition-duration:300ms;transition-duration:300ms;}.nav-global-wrap nav > ul li a:not(.banner).js-toggle-trigger:before{width:10px;height:2px;position:absolute;top:calc(50% - 1px);right:calc(1rem - 4px);content:'';display:block;background:#333;-webkit-box-sizing:border-box;box-sizing:border-box;}.nav-global-wrap nav > ul li a:not(.banner).js-toggle-trigger.is-open:after{-webkit-transform:rotate(270deg);-ms-transform:rotate(270deg);transform:rotate(270deg);-webkit-transform-origin:50% 50%;-ms-transform-origin:50% 50%;transform-origin:50% 50%;}.nav-global-wrap nav > ul > li{background:#eee;font-weight:bold;}.nav-global-wrap nav > ul > li ul{font-weight:normal;}.nav-global-wrap nav > ul > li ul > li{background:#fff;}.nav-global-wrap nav > ul > li ul > li > a:not(.banner){padding-left:1.5rem;border-top:1px solid #999;}.nav-global-wrap nav > ul > li ul > li:last-child{border-bottom:none;}.nav-global-wrap nav > ul > li ul > li ul > li > a:not(.banner){padding-left:2.5rem;border-top:1px dotted #999;text-indent:0;}.nav-global-wrap nav > ul > li ul > li ul > li > a:not(.banner):before{content:none;}.nav-global-wrap nav > ul.only-tab-sp > li{background:#fff;}.nav-global-is-content{padding:1rem .5rem;border-top:1px solid #999;-webkit-box-sizing:border-box;box-sizing:border-box;}.nav-global-is-content:after{content:'';height:0;visibility:hidden;display:block;clear:both;}.nav-global-is-content > .banner{float:left;border:1px solid #ccc;-webkit-box-sizing:border-box;box-sizing:border-box;padding:1rem;width:calc(50% - .25rem);display:block;height:60px;}.nav-global-is-content > .banner + .banner{margin-left:.5rem;}.mod-breadcrumb{padding:.625rem;}.nav-global .ico-member:before{content:url(/themes/custom/opdivo_theme/images/common/icon/locked-yellow.svg);}}@media screen and (min-width:1000px){header{position:relative;z-index:1;}header .header{padding:8px 20px;}header .header-logo{padding:12px 0;width:208px;float:left;clear:left;}header .header-description{float:right;clear:right;font-size:.75rem;}.nav-global{display:inherit;}.nav-global > .contents-container{padding-left:5px;padding-right:5px;padding-bottom:5px;background:#fff;position:relative;z-index:1;overflow:visible !important;}.nav-global-logos > a{vertical-align:top;display:inline-block;width:100px;margin-left:20px;}.nav-global-logos > a img{display:block;}.nav-global-switch{display:none;}.nav-global-status-menu{position:absolute;top:-40px;right:10px;z-index:99;font-size:.875rem;}.nav-global-status-menu > div{display:inline-block;vertical-align:middle;}.nav-global-greeting-wrap{margin-right:1rem;}.nav-global-btn,a.nav-global-btn{background:#cfe5ee;border-bottom:2px solid #b8cbd2;font-weight:bold;border-radius:4px;display:inline-block;color:#003b5c;text-decoration:none;padding:4px 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ul:after{content:'';visibility:hidden;clear:both;height:0;display:block;}.nav-global-wrap nav > ul > li{text-align:center;-webkit-box-sizing:border-box;box-sizing:border-box;border-right:1px solid #fff;background:#003b5c;width:calc(99.9999% / 7);float:left;height:40px;}.nav-global-wrap nav > ul > li > a{-webkit-box-sizing:border-box;box-sizing:border-box;font-size:.875rem;color:#fff;text-decoration:none;font-weight:bold;padding:0 4% 0 4px;position:relative;line-height:40px;display:block;height:100%;}.nav-global-wrap nav > ul > li > a.is-open,.nav-global-wrap nav > ul > li > a.is-active,.nav-global-wrap nav > ul > li > a:hover{background:#0d92be;}.nav-global-wrap nav > ul > li > a:after{content:'';display:block;height:13px;width:13px;-webkit-box-sizing:border-box;box-sizing:border-box;position:absolute;top:calc(50% - 6px);right:3%;background-image:url(/themes/custom/opdivo_theme/images/common/icon/arrow-right-thin-ffffff.svg);background-repeat:no-repeat;background-position:center 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a{display:block;height:3rem;line-height:3rem;background:#fff;color:#003b5c;text-decoration:none;position:relative;padding-left:2rem;-webkit-box-sizing:border-box;box-sizing:border-box;font-weight:bold;}.nav-global-wrap nav > ul > li > div:not(.nav-global-search) > ul > li > a:hover{opacity:.75;}.nav-global-wrap nav > ul > li > div:not(.nav-global-search) > ul > li > a.row2{line-height:1rem;padding-top:.5rem;padding-bottom:.5rem;}.nav-global-wrap nav > ul > li > div:not(.nav-global-search) > ul > li > a:before{content:'';display:block;height:13px;width:13px;-webkit-box-sizing:border-box;box-sizing:border-box;position:absolute;top:calc(50% - 6px);left:1rem;background-image:url(/themes/custom/opdivo_theme/images/common/icon/arrow-right-thin-014ea0.svg);background-repeat:no-repeat;background-position:center center;}.nav-global-wrap nav > ul > li > div:not(.nav-global-search) > ul > li > ul{margin-top:1px;background:#f2f6fa;font-size:.875rem;padding-bottom:14px;}.nav-global-wrap nav > ul > li > div:not(.nav-global-search) > ul > li > ul > li{width:50%;float:left;}.nav-global-wrap nav > ul > li > div:not(.nav-global-search) > ul > li > ul > li > .link-angle{color:#333;padding:10px 20px 0 2.2rem;display:block;}.nav-global-wrap nav > ul > li > div:not(.nav-global-search) > ul > li > ul:after{content:'';display:block;visibility:hidden;clear:both;height:0;}.nav-global-wrap nav > ul > li > div:not(.nav-global-search) > ul:after{content:'';display:block;visibility:hidden;clear:both;height:0;}.nav-global-wrap nav > ul > li > div:not(.nav-global-search) > ul.col4 > li{width:calc(100% / 4 - 10px);}.nav-global-wrap nav > ul > li > div:not(.nav-global-search) > ul.col2 > li{width:calc(100% / 2 - 10px);}}.contents-container{overflow:hidden;max-width:1200px;width:100%;-webkit-box-sizing:border-box;box-sizing:border-box;margin:auto;}.contents-container:after{content:'';display:block;visibility:hidden;height:0;clear:both;}.contents-container a img{display:block;width:100%;}@media screen and (min-width:1000px){.contents-container{padding:0 10px;}.nav-global + .contents-container{margin-top:1.875rem;}}.ttl-information{overflow:hidden;width:100%;font-weight:bold;border-bottom:1px solid #1a5fa9;-webkit-box-sizing:border-box;box-sizing:border-box;}.ttl-information-img{display:table-cell;width:20%;overflow:visible;}.ttl-information-img > img{width:640%;margin-left:-140%;display:block;}.ttl-information-caption{display:table-cell;width:80%;vertical-align:middle;color:#333;font-size:1.125rem;}.ttl-information-caption-text{width:100%;margin-left:-20%;line-height:100%;}.ttl-information-important{color:#c00;font-weight:bold;padding:1rem .8rem;border-bottom:1px solid #fff;border-top:solid #c00 3px;background:url(/themes/custom/opdivo_theme/images/common/icon/info_bg.png) no-repeat right 10px top 50%;}@media screen and (max-width:999px){.ttl-information-important{border-top:none;}.ttl-information-important.js-toggle-trigger{background:none;position:relative;}.ttl-information-important.js-toggle-trigger:after{width:8px;height:8px;position:absolute;top:calc(50% - 4px);right:1rem;content:'';display:block;border-top:1px solid #c00;border-right:1px solid #c00;-webkit-box-sizing:border-box;box-sizing:border-box;-webkit-transform:rotate(135deg);-ms-transform:rotate(135deg);transform:rotate(135deg);}.ttl-information-important.js-toggle-trigger.is-open:after{top:50%;-webkit-transform:rotate(-45deg);transform:rotate(-45deg);}}.txt-information-date{font-size:.75rem;}.txt-information-important-article-title{font-weight:bold;}.sec-information,.mod-information{margin-bottom:1.875rem;font-size:.875rem;background:#fff;}.sec-information ul{padding:1rem 0;}.sec-information ul:after,.mod-information ul:after{content:'';clear:both;visibility:hidden;height:0;display:block;}.sec-information ul > li,.mod-information ul > li{border-bottom:1px dotted #ccc;padding:.8rem;}.sec-information ul > li a,.mod-information ul > li a{font-weight:bold;word-wrap :break-word;overflow-wrap :break-word;}.mod-information ul > li a{display:block;}.sec-information-new{margin-bottom:1.875rem;font-size:.875rem;background:#fff;}.sec-information-new > [class*=ttl]{margin-bottom:0;}.sec-information-new ul{padding:1rem 0;}.sec-information-new ul > li{-webkit-box-sizing:border-box;box-sizing:border-box;padding:.6rem 0;display:table;width:100%;}.sec-information-new ul > li a{font-weight:bold;-webkit-box-sizing:border-box;box-sizing:border-box;padding:0 .8rem;display:table-cell;}.sec-information-new .txt-information-new-date{-webkit-box-sizing:border-box;box-sizing:border-box;padding:0 .75rem;font-size:.75rem;display:table-cell;border-right:1px solid #ccc;width:15%;}.sec-information-new .txt-information-new-article-title{-webkit-box-sizing:border-box;box-sizing:border-box;padding:0 .8rem;display:table-cell;font-weight:bold;border-right:1px solid #ccc;width:15%;text-align:center;}.sec-information-new .txt-information-new-article-title.red{color:#910050;}.sec-information-important{margin-bottom:1.875rem;background:#fee;}.sec-information-important-body{font-size:.875rem;}@media screen and (max-width:999px){.sec-information-important-body:not(.js-toggle-show):not(.js-toggle-animation).js-toggle-target{display:none;}}.sec-information-important-body > p{padding:.8rem;}.sec-information-important li{padding:.8rem;}.sec-information-important li:not(:first-child){border-top:1px solid #fff;}.sec-information-important li a{font-weight:bold;word-wrap:break-word;overflow-wrap:break-word;}@media screen and (max-width:767px){.ttl-information-img{overflow:visible;}.ttl-information-img > img{width:800%;margin-left:-300%;}.sec-information-new .txt-information-new-date{min-width:40%;display:inline-block;}.sec-information-new .txt-information-new-article-title{min-width:40%;display:inline-block;text-align:center;}.sec-information-new ul > li{border-bottom:1px dotted #ccc;}.sec-information-new ul > li a{padding-top:.8rem;display:block;}}@media screen and (max-width:999px){.sec-information-important.contents-right{margin-bottom:0;}.sec-information-important{border-bottom:solid #dcc2c2 2px;}}.mod-card{border:1px solid #ccc;background:#fff;position:relative;padding-bottom:.5rem;-webkit-box-pack:justify;-ms-flex-pack:justify;justify-content:space-between;margin-bottom:1.875rem;}.mod-card.is-new .mod-card-img:before{content:'NEW';display:inline-block;padding:.1rem .3rem;color:#fff;font-weight:bold;text-align:right;font-size:.875rem;position:absolute;right:0;top:0;z-index:1;}.mod-card.is-new .mod-card-img:after{content:'';display:block;border-top:1.5rem solid #d00;border-right:2rem solid #d00;border-left:2rem solid transparent;border-bottom:1.5rem solid transparent;position:absolute;right:0;top:0;width:.4rem;height:.3rem;-webkit-box-sizing:border-box;box-sizing:border-box;}.mod-card-caption{padding:10px;}.mod-card-img{position:relative;}.mod-card-img-caption{color:#fff;position:absolute;bottom:0;background:#003b5c;font-weight:bold;font-size:.75rem;width:100%;padding:.2rem 10px;-webkit-box-sizing:border-box;box-sizing:border-box;}.mod-card-img > img{width:100%;display:block;border:none;}.mod-card-captitle{font-size:.75rem;font-weight:bold;}.mod-card-capsource{font-size:.75rem;padding:.2rem 10px 0 10px;}.mod-card-side{-webkit-box-sizing:border-box;box-sizing:border-box;width:100%;display:block;margin-bottom:1.875rem;}.mod-card-side-title{overflow:hidden;-webkit-box-sizing:border-box;box-sizing:border-box;display:table;width:100%;}.mod-card-side-title-img{-webkit-box-sizing:border-box;box-sizing:border-box;display:table-cell;width:10%;overflow:visible;}.mod-card-side-title-img > img{width:1000%;}.mod-card-side-title-caption{-webkit-box-sizing:border-box;box-sizing:border-box;padding:0 1rem;display:table-cell;width:90%;vertical-align:middle;color:#fff;}.mod-card-side-title-caption > h2{margin-left:-10%;}.mod-card-side-caption{background:#f3f3f3;padding:1rem;}.mod-card-side-date{font-size:.875rem;}.mod-card-side-link{font-size:.875rem;}.mod-card-side-link > a{overflow-wrap:break-word;word-wrap:break-word;}.mod-card-side-text{font-size:.75rem;overflow-wrap:break-word;word-wrap:break-word;}.mod-side{margin-bottom:1.875rem;}.mod-side .btn-default{margin-bottom:0;}.mod-side-link{margin-bottom:1.875rem;border-top:1px solid #ccc;border-bottom:1px solid #ccc;padding:1rem 0.5rem 1rem 1rem;-webkit-box-sizing:border-box;box-sizing:border-box;}.mod-side-banner li + li{margin-top:10px;}.mod-side-banner a img{border:1px solid #ccc;-webkit-box-sizing:border-box;box-sizing:border-box;}.mod-side-banner .to-yervoy{display:none;}.mod-external-bnr 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.footer-nav{background:#eee;padding-bottom:1.875rem;}footer .footer-nav-link > li{padding-top:.2rem;font-size:.875rem;}footer .footer-nav-link > li > a{color:#333;}footer .footer-nav-link-title{font-weight:bold;}footer .footer-nav-link-title > a{color:#333;font-size:1rem;}footer .footer-nav-nav{margin-top:1.875rem;}footer .footer-copyrights{padding-bottom:1.875rem;background:#eee;border-top:1px solid #ccc;font-size:.75rem;}footer .footer-copyrights .contents-container{margin-top:1.875rem;}footer .footer-copyrights-links li{display:inline-block;font-size:.875rem;}footer .footer-copyrights-links li:not(:last-child){margin-right:2rem;}footer .footer-copyrights-links li a{color:#333;font-size:.75rem;}footer .footer-copyrights-logos{width:352px;}footer .footer-copyrights-logos > img{display:block;width:100%;}footer 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solid #003670;display:table;width:100%;padding:1rem 4px;}.nav-side__title-text{font-weight:bold;display:table-cell;padding-left:1rem;}.nav-side nav > ul{border-top:1px solid #ccc;border-bottom:1px solid #ccc;}.nav-side nav > ul > li{-webkit-box-sizing:border-box;box-sizing:border-box;display:table;width:100%;}.nav-side nav > ul > li > a{-webkit-box-sizing:border-box;box-sizing:border-box;vertical-align:middle;display:block;padding:15px 1rem 15px 2rem;font-weight:bold;}.nav-side nav > ul > li:not(:first-child) > a{border-top:1px dotted #ccc;}.nav-side nav > ul > li li{-webkit-box-sizing:border-box;box-sizing:border-box;display:table;width:100%;}.nav-side nav > ul > li li > a{-webkit-box-sizing:border-box;box-sizing:border-box;vertical-align:middle;display:block;padding:5px 1rem 5px 3rem;}.nav-side nav > ul > li li > a:first-child{padding-top:10px;}.nav-side nav > ul > li li > a:last-child{padding-bottom:10px;}.nav-side nav > ul > li li.is-active{padding:5px 0;}.nav-side nav > ul > 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*:last-child{margin-bottom:0;}.mod-article-list{margin-bottom:1.875rem;}.mod-article-list article{padding:1rem;-webkit-box-shadow:0 1px 0 0 #a3a39d;box-shadow:0 1px 0 0 #a3a39d;margin-bottom:1rem;border:1px solid #ccc;}.box-body > *:last-child{margin-bottom:0;}.box-body [class*=grid-col-] > *:last-child{margin-bottom:0;}.box-default{background:#fff;padding:1rem;margin-bottom:1.875rem;border:1px solid #ddd;}.box-default .box-title{padding:4px 0 14px 0;font-weight:bold;border-bottom:2px solid #333;}.box-default .box-body{padding-top:1rem;}.box-default.more-important{border-color:#c00;}.box-action{padding:1rem;margin:3rem 0;border:10px solid #d9ecff;}.box-action .ttl-box-action{font-size:1.125rem;padding:10px 0 12px;font-weight:bold;color:#008cba;text-align:center;}.box-action p{margin-bottom:1rem;}.box-toggle{margin-bottom:1.875rem;}.box-toggle .box-body{padding:1rem;border:1px solid #ddd;}.box-toggle-row{-webkit-box-sizing:border-box;box-sizing:border-box;display:table;padding:.2rem 0;width:100%;}.box-toggle-row .form-label,.box-toggle-row .form-rows,.box-toggle-row .form-input{margin-bottom:0;width:100%;}.box-toggle-row .form-label{border:none;}.box-toggle-label{display:table-cell;width:15%;min-width:6.3rem;-webkit-box-sizing:border-box;box-sizing:border-box;padding:0 1rem;vertical-align:top;}@media screen and (min-width:768px){.box-toggle-label{border-right:1px solid #bbb;}}.box-toggle-rows{display:table-cell;width:85%;padding:0 1rem;vertical-align:top;}@media screen and (max-width:767px){.box-toggle-row + .box-toggle-row{border-top:1px solid #ddd;}}.box-toggle .sub{-ms-flex-item-align:end;align-self:flex-end;}.box-toggle .sub .btn-default{margin-top:auto;margin-bottom:0;}.box-panel{padding:0;margin-bottom:1.875rem;}.box-panel .box-title{color:#003b5c;font-size:1.125rem;padding:1.5rem 1.25rem .875rem 1.25rem;font-weight:bold;border-bottom:none;background:#eee;}.box-panel .box-title a{font-size:1.125rem;}.box-panel .box-body{padding:1rem;border:.3125rem solid 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.box-fukidashi-row{border-top:1px dotted #ccc;}.box-fukidashi-row .form-label,.box-fukidashi-row .form-rows,.box-fukidashi-row .form-input{margin-bottom:0;width:100%;}.box-fukidashi-row .form-label{border:none;}.box-fukidashi-label{display:table-cell;width:15%;min-width:6rem;-webkit-box-sizing:border-box;box-sizing:border-box;padding:0 1rem;vertical-align:top;}@media screen and (min-width:768px){.box-fukidashi-label{border-right:1px solid #bbb;}}.box-fukidashi-rows{display:table-cell;width:85%;padding:0 1rem;vertical-align:top;}.box-border{margin-bottom:1.875rem;}.box-border-row{-webkit-box-sizing:border-box;box-sizing:border-box;display:table;vertical-align:top;padding:1rem 0;width:100%;border-bottom:1px dotted #ccc;}.box-border-row.combination{padding:0;display:flex;}.box-border-row.combination .box-border-label{padding:1rem 1rem 1rem 0;display:flex;border-right:1px dotted #ccc;box-sizing:border-box;min-width:30%;}.box-border-row.combination .box-border-rows{display:flex;width:100%;}.box-border-row.combination .box-border-rows-inner{display:flex;width:100%;}.box-border-row.combination .box-border-inner{display:flex;width:100%;}.box-border-row.combination .box-border-radio-box{display:flex;flex-direction:column;}.box-border-row.combination .box-border-radio-box label{display:flex;flex:1;justify-content:center;align-items:center;box-sizing:border-box;padding:10px;border-bottom:1px dotted #ccc;border-right:1px dotted #ccc;background:#eee;}.box-border-row.combination .box-border-radio-box label.current{background:transparent;}.box-border-row.combination .box-border-radio-box label:last-of-type{border-bottom:none;}.box-border-row.combination .box-border-radio-box label input{margin-right:8px;background:transparent;}.box-border-row.combination .box-border-search-box{display:flex;flex:1;align-items:center;padding-left:1rem;box-sizing:border-box;}.box-border-row.combination .box-border-search-checkbox{display:none;}.box-border-row:first-child{border-top:1px dotted #ccc;}.box-border-row .form-label,.box-border-row .form-rows,.box-border-row .form-input{margin-bottom:0;width:100%;}.box-border-row .form-label{border:none;}.box-border-label{display:table-cell;width:15%;min-width:6rem;vertical-align:top;}.box-border-label.middle{vertical-align:middle;}.box-border-label > span{color:#003b5c;font-weight:bold;font-size:.875rem;}.box-border-rows{display:table-cell;width:85%;vertical-align:top;}@media screen and (max-width:999px){.box-border-row.combination{display:block;}.box-border-row.combination .box-border-label{width:100%;border-bottom:1px dotted #ccc;border-right:none;}.combination.box-border-row .box-border-radio-box label{min-height:40px;display:block;font-size:13px;padding:10px;}.box-border-row.combination .box-border-radio-box label input{margin-bottom:3px;}}.js-toggle:not(.js-toggle-sp) .js-toggle-trigger{cursor:pointer;}.js-toggle-hide{display:none;height:0;}.js-toggle-show{display:inherit;}.js-toggle-animation{display:inherit;overflow:hidden;-webkit-transition-duration:300ms;transition-duration:300ms;-webkit-transition-property:height;transition-property:height;-ms-transition-duration:300ms;-ms-transition-property:height;}figure > a{display:block;position:relative;}.mod-modal-roupe{position:absolute;right:.3rem;bottom:.3rem;padding:1rem;border-radius:50%;background:rgba(255,255,255,0.5);}.mod-modal-roupe:after{content:url(/themes/custom/opdivo_theme/images/common/icon/zoom-in.svg);width:16px;height:16px;display:block;}figcaption{font-size:.875rem;}.mod-information .ttl-h2{margin-bottom:0;}.mod-information ul{padding:0;}.mod-information ul > li > p{width:100px;float:left;font-size:.75rem;-webkit-box-sizing:border-box;box-sizing:border-box;}.mod-information ul > li > span{width:120px;-webkit-box-sizing:border-box;box-sizing:border-box;display:inline-block;clear:left;vertical-align:middle;}.mod-information ul > li > div p{margin-top:.5rem;font-size:.75rem;word-wrap:break-word;overflow-wrap:break-word;}.mod-information .more-info{margin-top:15px;text-align:right;}.more-info [class*=btn-]{cursor:pointer;}.btn-default.more.btn-close:after{background-image:url(/themes/custom/opdivo_theme/images/common/icon/arrow-up-mid-ffffff.svg);}@media screen and (min-width:768px){.mod-information ul > li{display:-webkit-box;display:-ms-flexbox;display:flex;-webkit-box-align:start;-ms-flex-align:start;align-items:flex-start;padding:.8rem 0;}.mod-information ul > li > p{-ms-flex-preferred-size:110px;flex-basis:110px;-ms-flex-negative:0;flex-shrink:0;}.mod-information ul > li > span{-ms-flex-preferred-size:120px;flex-basis:120px;-ms-flex-negative:0;flex-shrink:0;}.mod-information ul > li > div{-webkit-box-sizing:border-box;box-sizing:border-box;padding:0 10px;-ms-flex-negative:2;flex-shrink:2;margin-top:-3px;width:-webkit-calc(100% - 230px);width:calc(100% - 230px);}.mod-information ul > li p + a{max-width:86%;}}.modal-information,.modal-question,.modal-ic,.modal-newsletter{background-color:#fff;width:96%;margin:auto;padding:20px 2%;backface-visibility:hidden;-webkit-backface-visibility:hidden;}.modal-question p{margin-bottom:12px;margin-bottom:1rem;font-weight:bold;text-align:center;}.modal-question small{display:block;}.modal-question .btn.decline{text-decoration:none !important;}.modal-question .btn:last-of-type{margin-bottom:0;}.modal-question .txt-question{font-size:28px;font-size:calc(28rem/16);text-align:center;color:#0d92be;}.modal-question .btn-default{font-size:24px;font-size:calc(24rem/16);}.modal-question .btn-default.auxiliary{color:#003b5c;}.modal-question .btn-default small{font-size:14px;font-size:calc(14rem/16);}@media screen and (min-width:768px){.modal-question,.modal-newsletter,.modal-ic{width:60%;}}@media screen and (min-width:1000px){.modal-question,.modal-newsletter,.modal-ic{padding:40px 10px;width:96%;max-width:420px;}}.modal-newsletter{padding:0;width:100%;}.modal-header{background:#004DA0;padding:20px;text-align:center;position:relative;}.modal-header > img{max-width:503.5px;width:100%;height:auto;}.modal-header-title{font-weight:bold;font-size:28px;font-size:calc(28rem/16);color:#fff;line-height:1;}.modal-body{padding:20px 2% 10px;}.modal-footer{padding:0 2% 20px;text-align:center;}.modal-body figure > img{border:none;}.modal-header .close{position:absolute;top:0;right:0;}.modal-body-left img,.modal-body-right img{max-width:100%;}@media screen and (min-width:768px){.modal-newsletter{width:64%;}.modal-body{padding:20px 4% 20px;}.modal-footer{padding:0 4% 45px;}}@media screen and (min-width:1000px){.modal-newsletter{max-width:720px;}.modal-body{padding:20px;overflow:hidden;}.modal-body-left{max-width:312px;float:left;width:48.75%;}.modal-body-right{max-width:320px;float:right;width:50%;}.modal-footer{padding:0 20px 25px;}}.modal-information{position:relative;max-width:768px;padding:20px;box-sizing:border-box;}.modal-information img{width:100%;height:auto;vertical-align:middle;border:none;}.modal-information .modal-information-close{width:32px;height:32px;cursor:pointer;position:absolute;top:16px;right:16px;}.modal-information .modal-information-close span{width:100%;height:2px;display:inline-block;box-sizing:border-box;position:absolute;top:50%;left:0;background-color:#0d92be;}.modal-information .modal-information-close span:first-of-type{transform:rotate(45deg);}.modal-information .modal-information-close span:last-of-type{transform:rotate(135deg);}.modal-information .modal-information-more{margin-bottom:2rem;}.modal-information .modal-information-item{border-bottom:1px dotted #ccc;padding-top:.5rem;}.modal-information .modal-information-item:last-of-type{border:none;}.mod-ranking{margin-bottom:1.875rem;}.mod-ranking__title{-webkit-box-sizing:border-box;box-sizing:border-box;border-top:3px solid #003670;display:table;width:100%;padding:1rem 4px;}.mod-ranking__title:before{content:'';background:url(/themes/custom/opdivo_theme/images/common/icon/crown.svg) no-repeat;display:table-cell;vertical-align:middle;width:36px;}.mod-ranking__title-text{font-weight:bold;display:table-cell;padding-left:1rem;}.mod-ranking > ul{border-top:1px solid #ccc;border-bottom:1px solid #ccc;}.mod-ranking > ul > li{-webkit-box-sizing:border-box;box-sizing:border-box;display:table;width:100%;padding:15px 0;}.mod-ranking > ul > li:not(:last-child){border-bottom:1px dotted #ccc;}.mod-ranking > ul > li > p{display:table-cell;vertical-align:middle;width:60px;text-align:center;}.mod-ranking > ul > li > p > span{font-size:1.5rem;display:inline-block;border-radius:50%;text-align:center;height:45px;width:45px;border-width:1px;border-style:solid;-webkit-box-sizing:border-box;box-sizing:border-box;}.mod-ranking > ul > li > p > span:before{content:'';display:inline-block;height:46px;width:0;vertical-align:middle;}.mod-ranking > ul > li > a{font-size:.875rem;width:calc(100% - 60px);-webkit-box-sizing:border-box;box-sizing:border-box;vertical-align:middle;display:table-cell;}.mod-ranking__1 span{color:#d4bf39;border-color:#d4bf39;}.mod-ranking__2 span{color:#aaaaaa;border-color:#aaaaaa;}.mod-ranking__3 span{color:#7c3d00;border-color:#7c3d00;}.sec-secondary .ttle-h2{font-size:1.25rem;font-weight:bold;color:#003b5c;display:inline-block;}.sec-secondary .ttle-h2 + .link-list{display:inline-block;float:right;}@media screen and (max-width:999px){.sec-secondary .ttle-h2 + .link-list{padding-left:.875rem;border-left:1px solid #ccc;}}.sec-secondary .ttle-h2 .ttl-wrap:after{content:'';visibility:hidden;height:0;display:block;clear:both;}.mod-card-side-title > a{display:block;text-decoration:none;}.mod-card-side-title > a img{width:1000%;}.mod-card.melanoma{padding-bottom:50px;background:url("/themes/custom/opdivo_theme/images/index/melanoma.png") no-repeat;background-position:calc(100% - 5px) calc(100% - 5px);background-size:62px;position:relative;}.mod-card.nsclc,.mod-card.mpm{padding-bottom:50px;background:url("/themes/custom/opdivo_theme/images/index/nsclc.png") no-repeat;background-position:calc(100% - 5px) calc(100% - 5px);background-size:62px;}.mod-card.mpm{background:url("/themes/custom/opdivo_theme/images/index/mpm.png") no-repeat;background-position:calc(100% - 5px) calc(100% - 5px);background-size:62px;}.mod-card.rcc{padding-bottom:50px;background:url("/themes/custom/opdivo_theme/images/index/rcc.png") no-repeat;background-position:calc(100% - 5px) calc(100% - 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div,.mod-card.mpm > div,.mod-card.rcc > div,.mod-card.hl > div,.mod-card.hn > div,.mod-card.gc > div,.mod-card.meso > div,.mod-card.nmsc > div,.mod-card.hcc > div{position:relative;z-index:1;}.mod-card.melanoma:after,.mod-card.nsclc:after,.mod-card.mpm:after,.mod-card.rcc:after,.mod-card.hl:after,.mod-card.hn:after,.mod-card.gc:after,.mod-card.meso:after,.mod-card.nmsc:after,.mod-card.hcc:after{content:'';display:block;height:100%;width:100%;background:rgba(255,255,255,0);position:absolute;top:0;left:0;}@media screen and (max-width:767px){.box-panel .box-body .grid-col-sp12 > .mod-article{padding:10px 0;}}.link-list-width-label{display:table;}.link-list-width-label .link-list{display:table-cell;padding-left:1rem;}.link-list-width-label .link-list-label{display:table-cell;font-size:.875rem;font-weight:bold;border-right:1px solid #ccc;padding-right:1rem;color:#003b5c;}@media screen and (max-width:767px){.link-list-width-label{border-top:none;display:block;}.link-list-width-label .link-list-label{display:block;border:none;padding:.75rem 0;}.link-list-width-label .link-list.horizontal{display:block;border-bottom:1px dotted #ccc;padding:0;}.link-list-width-label .link-list.horizontal > li{display:block;border-top:1px dotted #ccc;margin:0;}.link-list-width-label .link-list.horizontal > li .link-angle{padding:.75rem;position:relative;text-indent:0;display:block;}.link-list-width-label .link-list.horizontal > li .link-angle:before{position:absolute;right:10px;top:calc(50% - .3rem);}}.sec-information-latest{margin-bottom:1.875rem;}.sec-information-latest .ttl-information-latest{font-size:1.125rem;font-weight:bold;color:#003b5c;margin-bottom:.875rem;}.information-list li{margin-bottom:.75rem;}.information-list li .date{font-size:.75rem;display:inline-block;}.information-list li > a,.information-list li > span{font-size:.875rem;display:block;word-wrap :break-word;overflow-wrap :break-word;}@media screen and (min-width:768px){.information-list 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.form-input{width:34%;margin:.4rem 2% .4rem 0;}}.mod-selecter{margin-top:25px;}.mod-selecter .box-body{background:#eee;}.mod-selecter ul{width:100%;overflow:hidden;margin:0 auto;}.mod-selecter li{display:table;border-radius:4px;cursor:pointer;background-color:#fff;width:47.5%;margin:3px;min-height:60px;float:left;}.mod-selecter li > i,.mod-selecter li > span{display:table-cell;vertical-align:middle;text-align:center;font-weight:700;font-feature-settings :"pkna" 1;}.mod-selecter [class*=ico-cancer]{width:52px;height:52px;position:relative}.mod-selecter [class*=ico-cancer]:before{position:absolute;content:'';width:40px;height:40px;border-radius:50%;background-color:#fff;background-position:center center;background-repeat:no-repeat;background-size:36px 36px;top:10px;left:6px;}.mod-selecter [data-trigger='melanoma'] [class*=ico-cancer]:before{background-image:url(/themes/custom/opdivo_theme/images/common/icon/mark-melanoma.png);}.mod-selecter [data-trigger="nsclc"] 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[data-trigger="crc"] [class*=ico-cancer]::before{background-image:url(/themes/custom/opdivo_theme/images/common/icon/mark-crc.png);}.mod-selecter [data-trigger="cup"] [class*=ico-cancer]::before{background-image:url(/themes/custom/opdivo_theme/images/index/cup.png);}.mod-selecter [data-trigger="uc"] [class*=ico-cancer]::before{background-image:url(/themes/custom/opdivo_theme/images/common/icon/uc.png);}.mod-selecter [data-trigger="meso"] [class*=ico-cancer]::before{background-image:url(/themes/custom/opdivo_theme/images/common/icon/meso.png);}.mod-selecter [data-trigger="nmsc"] [class*=ico-cancer]::before{background-image:url(/themes/custom/opdivo_theme/images/common/icon/nmsc.png);}.mod-selecter [data-trigger="hcc"] [class*=ico-cancer]::before{background-image:url(/themes/custom/opdivo_theme/images/common/icon/hcc.png);}.mod-selecter{color:#003b5c;47.5%;}.mod-selecter li:hover,.mod-selecter .is-active{color:#fff;}.mod-selecter li:hover,.mod-selecter 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figcaption{font-size:.75rem;}.category-ms-article .mod-article-wraparound > figure.portrait figcaption{font-feature-settings :"palt" 1;letter-spacing:-0.06em;}.category-ms-article .mod-article-wraparound > figure.portrait figcaption p{font-size:.875rem;line-height:1.5;margin-bottom:0;}.category-ms-article .mod-article-wraparound > figure.portrait figcaption .txt-sentence + p{font-size:.75rem}.category-ms-article .grid-row.img-area{width:75%;margin:1rem auto;}.category-ms-article .img-area-col-1{width:35.366%;margin:1rem auto;}.category-ms-article .grid-row.img-area + .cap,.category-ms-article .img-area-col-1 + .cap{margin-top:-0.5rem;text-align:center;font-size:.75rem;}@media screen and (max-width:875px){.category-ms-article .grid-row.img-area .grid-col-sp12{width:55%;margin:0 auto;}.category-ms-article .grid-row.img-area .grid-col-sp12 + .grid-col-sp12{margin-top:.5rem;}}.category-ms-article .mod-article-wraparound .ttl-h3{margin-top:1.875rem;}.category-ms-article .mod-article-wraparound .ttl-h3.first-of-type{margin-top:0;}.category-ms-article .mod-footnote dd{margin-top:.5rem;}.category-ms-pdl1-article .script{font-family:serif;}.category-ms-pdl1-article .sec-secondary .txt-discussion > *{line-height:2;}.category-ms-pdl1-article .sec-secondary dl + figure,.category-ms-pdl1-article .sec-secondary p + figure{margin-top:1.875rem;}.category-ms-pdl1-article .sec-secondary figure.img_original img{border:none;}.category-ms-pdl1-article .sec-secondary figure.img_original a{max-width:820px;margin:0 auto;}.category-ms-pdl1-article.category-ms-pdl1-think .sec-secondary figure.img_original a{max-width:758px;}.category-ms-pdl1-article .btn-default.next{text-align:center;padding-left:2rem;padding-right:2rem;font-size:.875rem;}.movie-page .box-movie{width:100%;margin:1.875rem auto;position:relative;padding-bottom:56.25%;}.movie-page .box-movie.screen-raito-4-3{padding-bottom:75%;}.movie-page .sec-secondary{margin-top:1.875rem;}.movie-page .same-series-movies{margin:1.875rem 0;}.same-series-movies .mod-article{margin-bottom:1rem;}.same-series-movies .is-active img{opacity:.75;}.same-series-movies .is-active a{text-decoration:none;}.movie-page .same-series-movies .mod-article:last-child{margin-bottom:0;}.box-movie .jstream-eqPlayer,.box-movie object{width :100% !important;text-align:center;}.box-movie .jstream-eqPlayer .player_main{margin:0 auto;}.box-movie .errorDialogHeader img{width :auto;}@media screen and (min-width:768px){.movie-page .same-series-movies .mod-article:nth-child(-n+2),.has-backnumber .same-series .mod-article:nth-child(-n+2){border-top:none;padding-top:1rem;}.movie-page .same-series-movies .mod-article:nth-last-child(-n+2),.has-backnumber .same-series .mod-article:nth-last-child(-n+2){margin-bottom:0;}}.has-backnumber .same-series .is-active img{opacity:.75;}.has-backnumber .same-series .is-active a{text-decoration:none;}.sec-seminar{margin-bottom:2.875rem;}.sec-seminar .box-toggle{margin-bottom:1.0rem;}.sec-seminar .seminar-profile{border-bottom:1px dotted #b2b2b2;margin-bottom:1.0rem;}.seminar-list{border-bottom:1px dotted #b2b2b2;padding-bottom:0.5rem;margin-bottom:1.0rem;}.seminar-list:before,.seminar-list:after{content:" ";display:table;}.seminar-list:after{clear:both;}.seminar-list .img-thumb{float:right;width:90px;margin-left:1rem;}.seminar-list .seminar-list-inner:before,.seminar-list .seminar-list-inner:after{content:" ";display:table;}.seminar-list .seminar-list-inner:after{clear:both;}.seminar-list .ico-labels{margin-bottom:1.5rem;}.seminar-list .seminar-description{margin-bottom:0.875rem;}.seminar-date{overflow:hidden;}.seminar-date:before,.seminar-date:after{content:" ";display:table;}.seminar-date:after{clear:left;}.seminar-date .date{display:table;font-size:1.25rem;font-weight:bold;float:left;margin-bottom:0.875rem;line-height:1.5;vertical-align:middle;}.seminar-list .date .onair{color:#fff;background:#0d92be;display:table-cell;text-align:center;font-size:0.9em;font-weight:bold;width:6em;}.seminar-list .date span:nth-child(2){display:table-cell;padding:0 1em;}.seminar-list .date .live{color:#fff;background:#ab220f;display:table-cell;text-align:center;font-weight:bold;width:6em;vertical-align:middle;}@media screen and (max-width:767px){.seminar-list .date .onair{width:3.875em;}.seminar-list .date .live{width:3em;}}.seminar-list .date .live-inner-text{color:#ab220f;background:#ffeeee;display:table-cell;font-size:1.12rem;padding:0 1em;vertical-align:middle;}.seminar-list .ttl-seminar-title{color:#003b5c;font-size:0.875rem;font-weight:bold;}.seminar-list .ttl-seminar-subject,.seminar-list .ttl-seminar-subject a{font-size:1.25rem;margin-bottom:0.5rem;}.seminar-detail .ttl-h1{padding:0;width:100%;overflow:hidden;}.seminar-detail .txt-wrap{padding:1.875rem 0 0 0;width:100%;}.seminar-detail .ttl-h1 .series{width:100%;color:#003b5c;font-size:1.125rem;}.seminar-detail .ttl-h1 .shoulder{width:100%;font-size:0.875rem;color:#333;}.seminar-detail .ttl-h1 .title{width:100%;font-size:1.5rem;}.seminar-detail .mod-article{padding:1.875rem 0 0 0;}.seminar-detail .mod-article figure{background:#000;position:relative;z-index:0;}.seminar-detail .mod-article a:hover{background:#fff;}.seminar-detail .mod-article a,.seminar-detail .mod-article a:link,.seminar-detail .mod-article a:visited,.seminar-detail .mod-article a:hover{text-decoration:none;}.seminar-detail .mod-article img{opacity:0.5;}.seminar-detail .mod-article a:hover img{opacity:0.75;}.seminar-detail .mod-article a.is-disabled{background:#000;cursor:default;}.seminar-detail .mod-article a.is-disabled:hover img{opacity:0.5;}.seminar-detail .mod-article .is-movie > a{display:block;text-decoration:none;border:none;position:relative;}.seminar-detail .mod-article .is-movie.onair a:before,.seminar-detail .mod-article .is-movie.onlive a:before{top:32%;}.seminar-detail .mod-article .is-movie .inner-txt{position:absolute;display:block;color:#fff;font-size:1.0rem;top:16%;left:0;width:100%;min-height:auto;text-align:center;vertical-align:50%;margin:auto;z-index:0;}.seminar-detail .mod-article .is-movie.wait .inner-txt{top:35%;}.seminar-detail .mod-article .is-movie .heading{position:absolute;display:block;color:#fff;font-size:1.0rem;top:0;left:0;margin:auto;min-width:3em;padding:0em 0.5em;background-color:#0d92be;text-align:center;z-index:0;}.seminar-detail .mod-article .is-movie.onlive .heading{background-color:#de5900;}@media screen and (max-width:999px){.seminar-detail .mod-article .is-movie .inner-txt{font-size:2.2vw;}.seminar-detail .mod-article .is-movie .heading{font-size:1.8vw;}}@media screen and (max-width:767px){.seminar-detail .mod-article .is-movie .inner-txt{font-size:2.0vw;}.seminar-detail .mod-article .is-movie .heading{font-size:1.8vw;}}.seminar-date .date{margin-right :0.5rem;}.seminar-date .calendar-area{display:table;margin-left :0;margin-bottom:0.875rem;float:left;width:12rem;}@media screen and (max-width:767px){.seminar-date .date{float:none;}.seminar-date .calendar-area{margin-bottom:1rem;}.seminar-date .date{margin-right :0;}}.seminar-date .calendar-area .calender-area-inner{position:static;}.seminar-date .calendar-area label{display:block;cursor:pointer;font-size:.875rem;font-weight:bold;background:#fff;border:1px solid #ccc;border-radius:6px;box-sizing:border-box;color:#333;text-decoration:none;position:relative;text-align:center;-webkit-box-sizing:border-box;box-sizing:border-box;padding:.25rem 1.5rem;}.seminar-date .calendar-area label:before{position:absolute;left:.7rem;top:calc(50% - 8px);content:'';width:16px;height:16px;display:block;-webkit-box-sizing:border-box;box-sizing:border-box;background-image:url(/themes/custom/opdivo_theme/images/common/icon/calendar.svg);background-repeat:no-repeat;background-position:center center;}.seminar-date .calendar-area 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ul{width:12rem;font-size:.875rem;font-weight:bold;border-bottom-left-radius:6px;border-bottom-right-radius:6px;text-decoration:none;position:relative;text-align:center;-webkit-box-sizing:border-box;box-sizing:border-box;border:1px solid #ccc;border-top:none;padding:.25rem 0.5rem;position:absolute;top:0;left:0;z-index:90;color:#333;background:#fff;box-sizing:border-box;display:block;}.seminar-date .calendar-area li{border-bottom:1px dotted #ccc;width:100%;}.seminar-date .calendar-area li:last-child{border-bottom:none;}.ttl-h1.popup .date{font-size:1.25rem;font-weight:bold;}.seminar-movie-wrap{overflow:hidden;clear:both;margin-bottom:1.5rem;}.seminar-movie{float:left;width:69%;height:100%;overflow:hidden;padding:0;margin-right:1%;font-size:0;}.seminar-movie-inner{padding-top:56.25%;position:relative;}.seminar-movie-inner > iframe{position:absolute;top:0;left:0;width:100%;height:100%;}.seminar-movie-wrap.sample .seminar-movie{float:none;margin:0 auto;}.seminar-movie-wrap.sample .box-movie{margin-top:0;}.seminar-forms{background:#f3f3f3;padding:0.8rem;font-size:0.8rem;float:left;width:calc(30% - 1.6rem);margin:0;}#seminar-movie > .txt-sentence{padding:11rem 20px;text-align:center;}@media screen and (max-width:768px){.seminar-movie{float:none;width:100%;}.seminar-forms{float:none;width:calc(100% - 1.6rem);}}.seminar-forms textarea{resize:vertical;}.seminar-forms input[type="text"],.seminar-forms textarea{width:100%;}.switch-area{overflow:hidden;}.switch-area a{margin-left:0;margin-right:20px;float:left;}.mod-tab.seminar>.mod-tab-head>ul{display:block;}.mod-tab.seminar>.mod-tab-head>ul>li>a{width:130px;padding:10px 0;font-size:16px;color:#003b5c;}.mod-tab.seminar>.mod-tab-head>ul>li.is-active>a{color:#fff;}.mod-tab.seminar>.mod-tab-target>ul>li{margin-top:2rem;}@media screen and (max-width:1000px){.mod-tab.seminar>.mod-tab-head{display:none;}}.seminar-calendar{}.seminar-calendar .pager a.btn-back.is-disabled{color:#aaa;cursor:not-allowed;}.seminar-calendar .pager a.btn-back.is-disabled::before{display:none;}.seminar-calendar .pager a.btn-prev.is-disabled{color:#aaa;cursor:not-allowed;}.seminar-calendar .pager a.btn-prev.is-disabled::after{display:none;}.seminar-calendar .selected{font-size:1.125rem;padding-top:.45rem;margin:0 20px;font-family:Arial,sans-serif;font-weight:700;}.calendar{margin-bottom:1rem;}.calendar .head{display:flex;justify-content:space-between;}.calendar .head>.item{display:flex;height:30px;align-items:center;justify-content:center;text-align:center;border-top:1px solid #ddd;background-color:#eee;font-weight:700;}.calendar .head>.item.sunday{color:#b81c2b;background:#fff5f8;}.calendar .head>.item.saturday{color:#0e3192;background:#eceff7;}.calendar .body{display:flex;justify-content:space-between;flex-wrap:wrap;}.calendar .body>.item{min-height:84px;padding:4px;}.calendar .body>.item.past{position:relative;}.calendar .body>.item.past::after{content:"";position:absolute;top:0;left:0;width:100%;height:100%;z-index:10;background:#eee;opacity:.4;}.calendar .body>.item.today{background:rgba(66,163,219,0.1);}.calendar .item{width:14.28571%;border-right:1px solid #ddd;border-bottom:1px solid #ddd;box-sizing:border-box;}.calendar .item:nth-of-type(7n+1){border-left:1px solid #ddd;}.calendar .date{font-family:Arial,sans-serif;font-weight:700;font-size:16px;}.programs{}.program{}.program .start-at{font-family:Arial,sans-serif;font-size:14px;}.program .subject{word-break:break-all;word-wrap:break-word;font-weight:700;}.btn-default.icon-japanese:before{content:url(/themes/custom/opdivo_theme/images/common/icon/japanese.svg);width:1.25rem;display:inline-block;vertical-align:middle;margin-right:.5rem;margin-top:4px;}.btn-default.icon-english:before{content:url(/themes/custom/opdivo_theme/images/common/icon/english.svg);width:1.25rem;display:inline-block;vertical-align:middle;margin-right:.5rem;margin-top:4px;}.btn-default.icon-japanese span,.btn-default.icon-english span{font-size:90%;}.mod-catalog{overflow:hidden;margin:40px auto;}.mod-catalog li{display:block;background:url(/themes/custom/opdivo_theme/images/common/bg/line_dot_01.gif) repeat-x center top;position:relative;padding:1rem .25rem;box-sizing:border-box;}.mod-catalog li:nth-last-of-type(-n+1):after{content:'';position:absolute;width:100%;height:1px;background:url(/themes/custom/opdivo_theme/images/common/bg/line_dot_01.gif) repeat-x center top;left:0;bottom:0;}.mod-order{border:10px solid #c6e3f4;padding:1.875rem;text-align:center;}.mod-order p{font-size:.875rem;font-weight:bold;}.mod-order p + a,.mod-order p + button{margin-top:1.875rem;}.mod-order.before-login ul{margin-top:1rem;}form + .box-default{margin-top:3rem;}.material .img-wrap{text-align:center;}a .zoom{font-size:.75rem;text-align:center;}a .zoom:before{content:url(/themes/custom/opdivo_theme/images/common/icon/zoom-in-sm.svg);width:.8rem;display:inline-block;margin-right:.25rem;}.material figure > figcaption{text-align:left;}.material .category{margin-bottom:.25rem;}.material .category,.material .detail p,.material .detail time{font-size:.75rem;display:block;}.material .detail p + p{margin-top:.315rem;}.material .detail dt,.material .detail dt a{font-size:1rem;font-weight:bold;}.m-list-media__dl *{font-size:12px !important;font-weight:initial !important;}.material .detail dd{margin-top:.5rem;}.m-list-media__dd{margin-top:0 !important;}.m-list-media__dl{display:flex;flex-wrap:wrap;margin-top:auto;}.material figure + .btn-default.is-disabled{margin:1rem auto;}.material figure + div{margin:1rem auto;width:initial;padding:0;}.material figure + div.is-active{color:#003b5c;background-color:#9bd6ee;border-bottom:2px solid #7cabbe;}.material .auxiliary{color:#666;background-color:#f3f3f3;padding:.5rem;font-feature-settings :"pkna" 1;}.material figure{display:block;width:100%;}.material figure > *{display:table-cell;vertical-align:top;}.material .img-wrap{width:40%;padding-right:20px;text-align:center;}.material .img-wrap-clinical-path{width:40%;padding-right:20px;text-align:center;margin :0 auto;}.material figure + div[class*=btn-],.material figure + div[class*=btn-] *{cursor:pointer;}.material figure + div[class*=btn-] label{display:block;color:#003b5c;font-size:1rem;padding:0.675rem 0.675rem calc(.675rem - 2px) 0.675rem;}.material figure + div[class*=btn-] label > span{background-color:#fff;}@media screen and (min-width:768px){.mod-catalog{display:-webkit-box;display:-ms-flexbox;display:flex;-ms-flex-wrap:wrap;flex-wrap:wrap;-webkit-box-align:stretch;-ms-flex-align:stretch;align-items:stretch;-webkit-box-pack:start;-ms-flex-pack:start;justify-content:flex-start;width:104%;margin:40px -1.5%;}.mod-catalog li{display:-webkit-box;display:-ms-flexbox;display:flex;-webkit-box-orient:vertical;-webkit-box-direction:normal;-ms-flex-direction:column;flex-direction:column;-webkit-box-pack:justify;-ms-flex-pack:justify;justify-content:space-between;width:30%;margin:0 1.5%;}.mod-catalog li:nth-last-of-type(-n+3):after{content:'';position:absolute;width:100%;height:1px;background:url(/themes/custom/opdivo_theme/images/common/bg/line_dot_01.gif) repeat-x center top;left:0;bottom:0;}.mod-catalog li > *{min-height:0%;}.material figure + div{margin:1rem .3125rem;}.material .img-wrap{width:85px;padding-right:10px;}.material .auxiliary{font-size:.75rem;}}.js-select-category li br{display:none;}@media screen and (max-width:400px){.js-select-category li br{display:block;}}.table-responsive{width:100%;table-layout:auto;}.table-responsive thead{display:none;}.table-responsive tbody tr{display:block;width:100%;border:none;}.table-responsive tbody td{display:table;width:100%;border:1px solid #ccc;margin-top:-1px;padding:0;}.table-responsive tbody td > div{padding:1rem;display:table-cell;}.table-responsive tbody td:before{display:table-cell;padding:1rem;content:attr(data-label);white-space:nowrap;width:4.5em;font-weight:bold;color:#003b5c;background-color:#f3f3f3;border-right:1px solid #ccc;}.table-responsive tbody td:last-child{border:none;text-align:center;display:block;}.table-responsive tbody td:last-child > div{display:block;}.table-responsive tbody td:last-child a{display:inherit;color:#003b5c;width:100%;margin:1rem auto;}.table-responsive tbody td:last-child::before{display:none;}@media screen and (min-width:767px){.table-responsive tbody tr{display:table-row;}.table-responsive tbody td,.table-responsive thead th{display:table-cell;font-size:.875rem;padding:.875rem;vertical-align:top;text-align:left;}.table-responsive thead{display:table-header-group;}.table-responsive tbody td > div{padding:0;display:block;}.table-responsive tbody td:before{display:none;}.table-responsive tbody td:last-child{border:1px solid #ccc;display:table-cell;}.table-responsive tbody td:last-child a{display:block;padding:0.35rem 0.35rem calc(.35rem - 2px) 0.35rem;margin:0;width:75px;}.table-responsive tbody td:nth-child(5n){white-space:nowrap;}}@media screen and (min-width:1114px){.table-responsive tbody td:last-child a{width:130px;}}span[class^=category-label-],span[class^=type-label-]{font-size:.75rem;border-radius:10px;display:inline-block;text-align:center;font-weight:bold;width:130px;padding:2px auto;-webkit-box-sizing:border-box;box-sizing:border-box;}span[class^=type-label-]{font-size:.688rem;border-style:solid;border-width:1px;}@media screen and (min-width:999px) and (max-width:1211px){span[class^=category-label-],span[class^=type-label-]{width:100px;}}.type-label-path-p{border-color:#003a75;color:#003a75;}.type-label-path-e{border-color:#0059b2;color:#0059b2;}.type-label-single-p{border-color:#b5872e;color:#b5872e;}.type-label-single-e{border-color:#caa152;color:#caa152;}.type-label-chk-p{border-color:#238c00;color:#238c00;}.type-label-chk-e{border-color:#85b200;color:#85b200;}.type-label-region-alliance{border-color:#6a8b1d;color:#6a8b1d;}.type-label-heads-up{border-color:#d93600;color:#d93600;}.type-label-schedule{border-color:#00698c;color:#00698c;}.type-label-interview{border-color:#0085b2;color:#0085b2;}.type-label-patient{border-color:#b25900;color:#b25900;}.type-label-agreement{border-color:#7b3e00;color:#7b3e00;}.type-label-other{border-color:#868695;color:#868695;}.nav-top-page{background:#b2deef;padding:8px;width:100%;-webkit-box-sizing:border-box;box-sizing:border-box;display:table;}.nav-top-page-main{display:table;width:100%;height:100%;border-top:2px solid #b2deef;border-bottom:2px solid #b2deef;-webkit-box-sizing:border-box;box-sizing:border-box;height:150px;}.nav-top-page-main-col{display:table-cell;background:#fff;width:50%;height:100%;border-left:2px solid #b2deef;border-right:2px solid #b2deef;-webkit-box-sizing:border-box;box-sizing:border-box;vertical-align:bottom;padding:.5rem;position:relative;overflow:hidden;}.nav-top-page-main-col:nth-child(2){border-right:0;}.nav-top-page-main-col:hover{opacity:.75;}.nav-top-page-main-col img{position:absolute;display:block;top:0;left:0;width:100%;border:none;}.nav-top-page-main-col a{text-decoration:none;}.nav-top-page-main-col a > span{position:relative;z-index:1;color:#003b5c;font-size:1.125rem;font-weight:bold;position:relative;padding-right:1.125rem;display:inline-block;}.nav-top-page-main-col a > span:after{position:absolute;top:calc(50% - .5rem);right:0;content:'';display:block;height:1rem;width:1rem;background:url(/themes/custom/opdivo_theme/images/common/icon/arrow-up-mid-f15300.svg) no-repeat;background-position:right center;text-decoration:none;}.nav-top-page-main-col a > p{position:relative;z-index:1;font-size:.75rem;color:#333;}.nav-top-page-sub{display:table;width:100%;height:150px;-webkit-box-sizing:border-box;box-sizing:border-box;}.nav-top-page-sub-row{background:#b2deef;}.nav-top-page-sub-col,a.nav-top-page-sub-col{display:flex;align-items:center;width:calc(100% - 10px);height:46px;border-left:2px solid #b2deef;border-top:2px solid #b2deef;border-bottom:2px solid #b2deef;-webkit-box-sizing:border-box;box-sizing:content-box;vertical-align:middle;padding:0 0 0 .5rem;color:#004e90;text-decoration:none;font-weight:bold;background:url(/themes/custom/opdivo_theme/images/common/icon/arrow-up-mid-003b5c.svg) #d9eff7 no-repeat;background-color:#d9eff7;background-position:right .75rem center;}.nav-top-page-sub-col:hover,a.nav-top-page-sub-col:hover{opacity:.75;}@media screen and (max-width:999px){.nav-top-page{margin-bottom:1.875rem;}}@media screen and (min-width:768px){.nav-top-page-main{width:66.7%;float:left;}.nav-top-page-sub{width:33.2%;float:right;}.nav-top-page:after{content:'';display:block;visibility:hidden;height:0;clear:both;}}@media screen and (min-width:768px) and (max-width:999px){.nav-top-page-sub-col{height:39px;}}.box-important{background:#fee;padding:1.125rem;margin-bottom:1.875rem;}.box-important > *:last-child{margin-bottom:0;}.main-visual{background-repeat:no-repeat;background-position:center top;}.main-visual .contents-container{width:100%;position:absolute;top:0;bottom:0;left:0;right:0;margin:auto;}.main-visual-inner{display:table;width:100%;height:100%;}.main-visual-caption{display:table-cell;vertical-align:middle;color:#008cba;font-size:1.5rem;font-weight:bold;}.main-visual-caption > span{display:block;color:#003b5c;font-family:YuMincho,'Yu Mincho',"ヒラギノ明朝 ProN W6","HiraMinProN-W6","HG明朝E","ＭＳ Ｐ明朝","MS PMincho","MS 明朝",serif;width:52%;padding:1rem 0 1rem 1rem;-webkit-box-sizing:border-box;box-sizing:border-box;background:#fffc;background-color:rgba(255,255,255,0.8);}.special-message{position:relative;z-index:1;}.special-message h2{color:#C00;text-decoration:underline;margin-bottom:.875rem;}.js-special-message-inner{position:absolute;width:100%;-webkit-box-sizing:border-box;box-sizing:border-box;}.special-message-inner{width:100%;-webkit-box-sizing:border-box;box-sizing:border-box;margin-bottom:8px;padding:1rem;background:rgba(255,255,255,0.8);background:#fff;}.special-message-inner a{display:inline-block;}.special-message-inner a img{width:auto;max-width:100%;-webkit-box-sizing:border-box;box-sizing:border-box;border:1px solid #ccc;}.special-message-inner.banner{margin-top:15px;padding:0;background-color:transparent;}@media screen and (max-width:767px){.main-visual{background-size:125%;background-position:40% 45%;position:relative;padding-top:20%;padding-bottom:20%;}.main-visual-caption{font-size:1rem;}}@media screen and (min-width:768px) and (max-width:999px){.main-visual{background-size:130%;background-position:35% 45%;position:relative;padding-top:17%;padding-bottom:17%;}.main-visual-caption{font-size:1.3125rem;}}@media screen and (max-width:999px){.main-visual{position:relative;}.main-visual .contents-container{position:absolute;}}@media screen and (min-width:1000px){.main-visual{width:100%;position:absolute;top:-30px;left:0;padding-top:330px;padding-bottom:330px;}.main-visual .contents-container{max-width:1200px;}.main-visual-caption > span{max-width:460px;}.special-message-inner.banner{margin-top:0;}}.opdivo-top .main-visual{background-image:url(/themes/custom/opdivo_theme/images/index/main.jpg);}@media screen and (max-width:999px){.opdivo-top .mod-card-side.contents-right{padding-left:10px;padding-right:10px;}.opdivo-top .contents-left + .box-panel{padding-left:10px;padding-right:10px;}.opdivo-top .contents-left + .box-panel .grid-col-6{width:100%;}.opdivo-top .contents-left + .box-panel .grid-col-6 > .mod-article{padding:10px 0;}}@media screen and (min-width:768px) and (max-width:999px){.opdivo-top .contents-left + .box-panel,.opdivo-top .mod-card-side.contents-right{width:50%;-webkit-box-sizing:border-box;box-sizing:border-box;float:left;}}@media screen and (min-width:1000px){.opdivo-top .contents-left + .box-panel{width:calc(100% - 300px);float:left;}.opdivo-top .box-panel + .mod-card-side.contents-right,.opdivo-top .box-panel + .mod-card-side.contents-right ~ .contents-right{float:none;display:inline-block;margin-left:40px;}}@media screen and (min-width:768px) and (max-width:999px){.top-page-layout .contents-right .grid-col-tb6{margin-top:0;padding-top:10px;padding-bottom:10px;}.top-page-layout .contents-right .grid-col-tb6:nth-child(2n - 1){padding-right:0;padding-left:10px;}.top-page-layout .contents-right .grid-col-tb6:nth-child(2n){padding-left:0;padding-right:10px;}}@media screen and (max-width:767px){.top-page-layout .contents-main-body{padding:10px;}.top-page-layout .grid-col-sp6.mod-card{margin-bottom:10px;}.top-page-layout .grid-col-sp6.mod-card:nth-child(n + 3){margin-bottom:1.875rem;}.top-page-layout .contents-right .mod-card-side,.top-page-layout .contents-right .mod-ranking{padding:10px;}.top-page-layout hr{display:none;}}@media screen and (min-width:1000px){.nav-global + .contents-container.top-page-layout{margin-top:336px;}.top-page-layout .contents-main-body{padding:1.875rem 0;background:none;}}.top-page-layout .contents-left{position:relative;z-index:1;}.top-page-layout hr.dotted{margin:0 0 10px 0;}.top-page-layout .sec-information-important{position:relative;z-index:1;}.product-info-list{margin-bottom:1.875rem;}.product-info-list-row{background:#f3f3f3;-webkit-box-sizing:border-box;box-sizing:border-box;width:100%;margin-bottom:1px;}.product-info-list-row:after{content:'';display:block;visibility:hidden;height:0;clear:both;}.product-info-list-label{padding:1rem;-webkit-box-sizing:border-box;box-sizing:border-box;float:left;width:25%;font-weight:bold;font-size:.875rem;color:#003b5c;}.product-info-list-content{padding:1rem 1rem 1rem 0;-webkit-box-sizing:border-box;box-sizing:border-box;float:left;width:75%;}@media screen and (max-width:767px){.product-info-list-label{float:none;width:100%;}.product-info-list-content{padding:0 1rem 1rem 1rem;float:none;width:100%;}.grid-col-sp12:not(:last-child) .link-bill{margin-bottom:.75rem;}}@media screen and (min-width:768px){.product-info-list .grid-col-6:nth-child(n + 2) + .grid-col-6{margin-top:.75rem;}}.link-bill{border:1px solid #ccc;border-radius:6px;padding:.75rem;padding-right:1.875rem;background:#fff;text-decoration:none;color:#333;display:block;position:relative;}.link-bill.pdf:after{content:url(/themes/custom/opdivo_theme/images/common/icon/pdf.svg);}.link-bill.blank:after{content:url(/themes/custom/opdivo_theme/images/common/icon/blank.svg);}.link-bill.zip:after{content:url(/themes/custom/opdivo_theme/images/common/icon/zip.svg);}.link-bill.arrow:after{content:url(/themes/custom/opdivo_theme/images/common/icon/arrow-right-mid-333.svg);width:7px;}.link-bill:after{position:absolute;height:14px;width:14px;display:inline-block;top:calc(50% - 8px);right:.75rem;}.link-bill > .title{font-weight:bold;font-size:.875rem;}.link-bill > .date{font-size:.75rem;}.link-bill:hover{opacity:.75;}.list-order-ttl{counter-reset:decimal;}.list-order-ttl li{font-weight:bold;position:relative;}.list-order-ttl li:before{counter-increment:decimal;width:1em;content:counter(decimal) '. 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